518 Mechanobiology of Cells in Regenerative Medicine

Elisa Budyn, Ecole Normale Superieure de Cachan / University of Illinois at Chicago
Patrick Chabrand, Université de la Mediterranée
Thierry Hoc, Ecole Centrale Lyon
Rob Krams, Imperial College London
When the human body experiences large loss of tisssue, new types of therapies in regenerative medicine using stem cells or various cellularized substrates can now be considered while they could not be technically envisioned in the past. New pharmaceuticals can also be tested in vitro on human tissues in organ-on-chips. These technologies open new avenues to investigate the fundamental physiology of human cells in situ and further design high performance graft systems. These technologies offer the opportunity for studying almost any biological systems and improving transplation techniques with patient-specific scaffolds and/or patient-specific engineering cell for cellularized systems. 
Adding both recent technological advances in experimental techniques and photonics, high resolution imaging-based computational models have become more frequent to investigate cell mechanotransduction pathways and matrix formation down to the nano scale. Multi-physics and multi-scale computational methods contribute to the construction of theoretical models that make it possible to understand the complexity of the constitutive behaviors of biological tissues in parallel to the cell response. Despite the tremendous challenges these methods are facing, collaborative experimental and theoretical efforts have the potential to overcome scientific barriers quickly, transform the bioengineering community and advance tissue engineering and regenerative medicine through the diverse combinations of stem cells and innovative micro-environment.
This symposium will consider multi-scale multi-physics modeling of human cell and tissue mechanics and mechanobiology in biological systems promoting tissue growth. This symposium will particularly focus modeling and experimental validation for regenerative medicine and organ-on-chip using native, synthetic or 3D printed scaffolds. Algorithms for image processing of high resolution microscopy and algorithms for 3D volume reconstruction and segmentation are welcome. The tissues considered include cardiac, connective, muscle, neural, epithelial, endothelial tissues and others. Are welcome solid mechanics studies of the musculoskeletal system and soft tissues as well as fluid structure interaction models for cardiovascular descriptions and endothelial cells mechanics. Growth models to describe the mechanics of cells at the interface between the newly formed matrix or with biocompatible materials are very welcome. 
Targeted themes: 
Cell mechanics and modeling, multi-scale and multi-physics models, cell mechanobiology, cell interactions, cell-substrate interaction, cell growth, cell imaging, cell mechanosensing and mechanotransduction.
Tissue mechanics and characterization, tissue/tumor growth, tissue pathological evolution, tissue imaging.
Tissue and cell engineering, stem cells.
Regenerative medicine, organ-on-chip.